Registration Dossier
Registration Dossier
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EC number: 401-990-0 | CAS number: 106990-43-6 CHIMASSORB 119; LOWILITE 19
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Vehicle:
- water
- Remarks:
- containing 4% carboxymethylcellulose sodium salt
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- Male: 5000 mg/kg bw
Number of animals: 5
Number of deaths: 1
Female: 5000 mg/kg bw
Number of animals: 5
Number of deaths: 1 - Clinical signs:
- Signs of toxicity related to dose levels: sedation, dyspnea, ataxia (males), curved body position, ruffer fur. The surviving animals recovered within 7 days.
- Gross pathology:
- Effects on organs:
Lung: dark-red mottled, not collapsed.
Intestines/stomach: meteorism filled with yellowish contents
Killed animals
Lung: dark-red mottled (in 2 animals) - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The acute oral toxicity was investigated following the OECD Guideline 401 more than 12 years ago, under GLP conditions.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Vehicle:
- water
- Remarks:
- containing 4% carboxymethylcellulose sodium salt
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw
Number of animals: 5
Female: 2000 mg/kg bw - Gross pathology:
- Effects on organs:
No macroscopic organ changes were observed - Other findings:
- Signs of toxicity (local):
all the male rats showed a slight erythema at day 2, but recovered within 5 days.
All the females rats showed a slight erythema at day 3 until termination of observation. - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- DL50 > 2000 mg/kg
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The acute dermal toxicity was investigated following the OECD Guideline 402 more than 12 years ago, under GLP conditions.
Additional information
Only one study available
Justification for selection of acute toxicity – inhalation endpoint
Study scientifically unjustified.
Justification for selection of acute toxicity – dermal endpoint
Only one study available
Justification for classification or non-classification
No significant signs of toxicity are observed in acute oral and dermal studies in rat. Both LD50 are > 2000 mg/kg bw.
The test substance does not required classification for acute toxicity.
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