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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 9-11 1986; final report prepared in 2009
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptable restrictions and without analytical monitoring
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
yes
Remarks:
only 48 h exposure
Principles of method if other than guideline:
The test was performed according to guideline DIN 38412/15 with only 48h static exposure.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Details on test solutions:
PREPARATION AND APPLICATION OF TEST SOLUTION:
preparation of stock solution:
The test substance was weighted directly into the test vessels, filled up with standard dilution water to a final volume of 5 l and than stirred by ultrasound.
Test organisms (species):
Leuciscus idus
Details on test organisms:
TEST ORGANISM
- Common name: golden orfe
- Length at study initiation: approx. 6 cm long
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Hardness:
16° dH (about 93 mg/l Ca, 12 mg/l Mg)
Test temperature:
20 °C
pH:
7.8 - 8.2
Dissolved oxygen:
68-98%
Details on test conditions:
TEST SYSTEM
- Test vessel: fish basins containing 10 l test water
- No. of organisms per concentration (replicates): 10

OTHER TEST CONDITIONS
- Photoperiod: 16h/day
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
3 000 - 10 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
yes
Conclusions:
The letal concentration of 1-Dodecanol, 2-octyl- (Eutanol G) was determined to be LC50: > 5500 mg/l. Eutanol G is scarcely toxic to Golden orfe.
Executive summary:

Golden orfes (Leuciscus idus) were exposed for 48 h to 1-Dodecanol, 2-octyl- (Eutanol G) to determine the LC50. Under static test conditions the LC50 after 48 h was determined to be: LC50: > 5500 mg product /l. Therefore, 1-Dodecanol, 2-octyl- (Eutanol G) is considered to be scarcely toxic to Golden orfe.

Description of key information

Key value for chemical safety assessment

LC50 for freshwater fish:
5 500 mg/L

Additional information

2-Octyldodecan-1-ol is a member of the Guerbet Alcohols, which comprises a range of branched long chain alcohols C12-32. It is also structurally related to the substances of the OECD SIDS Long Chain Alcohols (LCA) categories, comprising a range of straight and branched long chain alcohols C6-22.

Experimental data for the Guerbet and LCA categories has been evaluated and trends in the environmental fate of long chain alcohols was used to extrapolate to other member of the category for ecotoxicological endpoints.

Reliable studies are available for four representatives of the Guerbet alcohols category; 2-butyloctan-1-ol, 2-hexyldecan-1-ol, 2-octyldodecan-1-ol, and alcohols C32-36 branched.

Only with the short chain Guerbet alcohol 2-butyloctanol acute toxicity was observed in the fish. The C12 Guerbet alcohol showed acute toxicity to Oncorhynchus mykiss with an effects concentration of 0.48 mg/L. In contrast, no acute toxicity to fish at the level of water solubility was observed for 2-hexyldecanol, 2-octyldodecanol and branched C32-36 alcohols as with their equivalent linear analogues (C16, C20 and C32-36 long chain alcohols). Acute effects data for two fish species ranged from 3,000 mg/L to >10,000 mg/L. This is in agreement with the findings of the OECD SIDS report (described above) that the longest chain alcohols are unlikely to exhibit acute toxicity to aquatic organisms at the low solubility limits.