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EC number: 405-820-6
CAS number: 30025-38-8
At 1000 mg/kg bw/day the only reactions of adults was pre-dose
salivation which was intermittent and thought to be reflex response to
test material that is either slightly irritant of 'foul' tasting. Also
at the highest dosage there was an apparent decrease in offspring
viability from birth to Day 4 post-partum due to larger group mean
litter size at birth resulting in an increased number of deaths over the
first 4 days of lactation. This was not considered an effect
attributable to treatment. At 1000 and 225 mg/kg bw/day there was an
increase in the incidence and severity of basophilic renal tubules of
male rats only; this was not unexpected as a manifestation of known
'male rat hydrocarbon nephropathy' (Alden CL (1986). A review of
unique male rat hydrocarbon nephropathy. Toxicologic Pathology Vol 14,
No 1, pp 109 -111). This was not, however a reproductive
At 50 mg/kg bw/day there were no significant treatment-related findings
in either sex.
Summary of live birth and viability indices
Live birth index (%)
Viability index %
Mean litter sizes during lactation
Mean # born
Days post partum
In a single generation OECD415 guideline study, Dipropylene Glycol
Monoethyl Ether is not reprotoxic in the rat at dosages greater than
those demonstrably toxic in male rats . The NOAEL (all reproductive
measures) and in females was 1000 mg/g bw/day. The toxic NOAEL in males
(only) was 50 mg/kg bw/day, a dosage that evokes male unique hydrocarbon
nephropathy at a dose of 225mg/kg and above.
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