Registration Dossier

Administrative data

Description of key information

Two guideline tests to evaluate either dermal irritancy or ocular irritancy of DPGEE in the rabbit were negative by accepted EU criteria.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Justification for classification or non-classification

SKIN: The level of response of all end points was insufficient to trigger classification under directive 67/548 or regulation 1272/2008.

EYE: The level of response of all end points was insufficient to trigger classification under directive 67/548 or regulation 1272/2008. Details shown below:

Mean of measurements at 24, 48, 72 hours

 

 

Animal 1

Animal 2

Animal 3

Classification under 67/548

Classification under 1272/2008

Corneal effects

1

0.3

0.3

No

No

Iritis

0

0

0

No

No

Conjunctival effects

1.7

1.7

1.0

No

No

Chemosis

1.0

0.7

0.3

No

No