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EC number: 405-820-6
CAS number: 30025-38-8
There are a limited number of degradation studies available on the
substance dipropylene glycol ethyl (DPGEE) ether. In a
guideline OECD301F study, DPGEE was not readily biodegradable, reaching
only 38 -43% by day 28. However, the study showed a long lag phase of 10
-20 days and, more importantly, the reference substance did not reach
the required level of degradation in 14 days required in the study
guideline for the study to be valid. This result can be considered
reliable as an indicator that the substance is degradable but it is not
a reliable ready biodegradation study . The substance
was also assessed in a guideline inherent biodegradation study. A
biodegradation rate greater than 70% (98%) in this test confirmed
inherent ultimate biodegradability and therefore low potential for
Biodegradation studies have also been
performed on the two substances either side of DPGEE in the homologous
series of dipropylene glycol n-alkyl ethers. Dipropylene
glycol methyl ether (DPGME) was evaluated for ready biodegradability
following the OECD Method 301F. Oxygen consumption and CO2evolution
resulting from biodegradation of the compound was measured over a 28-day
test. The average
extent of biodegradation based on O2consumption at the end of the 10 day
window was 75%. The
extent of biodegradation based on CO2production (DCO2) and DOC removal
for DPGME after 28 days was 76% and 96% respectively. DPGME
can be classified as “readily biodegradable”, meeting the 10 day window. In
a guideline and GLP study, the substance dipropylene glycol monopropyl
ether (DPGPE) was found to be readily biodegradable when tested
according to guideline OECD301A study. A degradation of 92% was found at
the end of the 23 day study.
In conclusion, DPGEE is clearly at least inherently biodegradable. In
a ready biodegradation study 38-43% degradation was seen after 28 days
but the innoculum was shown to be below acceptable levels of activity as
the reference substance degraded more slowly than accepted for a valid
study. There is data on the two glycol ethers either
side of DPGEE in the homologous series, DPGME and DPGPE, that show that
both of these substances are readily biodegradable. There
is no credible reason why these should be readily biodegradable and
DPGEE not. Considering the weight of evidence, it is
concluded that DPGEE is likely to be readily biodegradable.
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