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Ecotoxicological information

Toxicity to microorganisms

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Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data for various test chemicals
Justification for type of information:
experimental data for various test chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: Refer below principle
Principles of method if other than guideline:
WoE report is prepared based on toxicity to microorganisms study:
2, 3
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Vibrio fisheri
Test type:
static
Water media type:
other: 2nd and 3rd: Marine Water
Total exposure duration:
30 min
Remarks on exposure duration:
toxicity data to vibrio fisheri (the acute Microtox test) at each of the 5, 15 and 30-min endpoints.
Reference substance (positive control):
no
Key result
Duration:
35 min
Dose descriptor:
other: pT35
Remarks:
pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the 35 min
Effect conc.:
1.09 mmol/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: concentration required to elicit a 50% reduction in light emission
Remarks on result:
other: 2nd study
Duration:
30 min
Dose descriptor:
other: pT35
Remarks:
pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the 35 min
Effect conc.:
1.52 mmol/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: concentration required to elicit a 50% reduction in light emission
Remarks on result:
other: 2nd study
Validity criteria fulfilled:
no
Conclusions:
2nd: Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30 was predicted to be 1.09.

3rd: Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30 was predicted to be 1.52.
Executive summary:

First study provide a means to predict the ‘minimum’ toxicity that a phenol willexert in the Microtox test.Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30 was predicted to be 1.09.

First study was supported by second from peer reviewed journal, provide a means to predict the ‘minimum’ toxicity that a phenol willexert in the Microtox test.Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30, pT15 and pT5 was predicted to be 1.52, 1.59 and 1.66 respectively.

Description of key information

Study provide a means topredict the ‘minimum’ toxicity that a phenol willexert in the Microtox test.Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30 was predicted to be 1.09.

Key value for chemical safety assessment

EC50 for microorganisms:
1.09 mg/L

Additional information

First study provide a means topredict the ‘minimum’ toxicity that a phenol willexert in the Microtox test.Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30 was predicted to be 1.09.

First study was supported by second from peer reviewed journal, provide a means topredict the ‘minimum’ toxicity that a phenol willexert in the Microtox test.Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30, pT15 and pT5 was predicted to be 1.52, 1.59 and 1.66 respectively.