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Solubility in organic solvents / fat solubility

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Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Data is from experimental study report
Qualifier:
according to
Guideline:
other: Gravimetric method
Principles of method if other than guideline:
Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2,2,2-trichloro-1-phenylethyl acetate
- Molecular formula: C10-H9-Cl3-O2
- Molecular weight: 267.538g/mol
- Smiles notation: c1([C@@H](OC(C)=O)C(Cl)(Cl)Cl)ccccc1
- InChl: 1S/C10H9Cl3O2/c1-7(14)15-9(10(11,12)13)8-5-3-2-4-6-8/h2-6,9H,1H3
- Substance type: Organic
- Physical state: solid
Key result
Medium:
methanol
Solubility:
35 900 mg/L
Temp.:
25 °C
Remarks on result:
other: No details available
Conclusions:
The solubility of the test chemical in methanol is observed to be 35900 mg/L at 25 degC by using Gravimetric method.
Executive summary:

The solubility of the test chemical in methanol is observed to be 35900 mg/L at 25 degC by using Gravimetric method. This value indicates that the substance is very soluble in alcohol.

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Justification for type of information:
Data is from experimental study report
Qualifier:
according to
Guideline:
other: Soxhlet/Solvent extraction method
Principles of method if other than guideline:
Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Key result
Medium:
other: Petroleum ether
Solubility:
40 100 mg/L
Temp.:
25 °C
Conclusions:
Solubility of the test chemical in Petroleum ether is determined to be 40100 mg/L at 25°C by using Soxhlet/Solvent extraction method.
Executive summary:

Solubility of the test chemical in Petroleum ether is observed to be 40100 mg/L at 25°C by using Soxhlet/Solvent extraction method. This value indicates that the substance is very soluble in petroleum ether.

Description of key information

The solubility of the test chemical in methanol is observed to be 35900 mg/L at 25 degC by using Gravimetric method. This value indicates that the substance is very soluble in alcoho. This value is equivalent to 28720 at 20 °C.

Using the Soxhlet/Solvent extraction method the solubility of the test chemical in Petroleum ether is observed to be 40100 mg/L at 25 °C.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
28 720 mg/L

Additional information

The solubility of the test chemical in methanol is observed to be 35900 mg/L at 25 degC by using Gravimetric method. This value indicates that the substance is very soluble in alcoho.This value is equivalent to 28720 at 20 °C.

Using the Soxhlet/Solvent extraction method the solubility of the test chemical in Petroleum ether is observed to be 40100 mg/L at 25 °C.