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PBT assessment

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PBT assessment: overall result

Reference
Name:
2,2,2-trichloro-1-phenylethyl acetate
Type of composition:
legal entity composition of the substance
State / form:
solid: bulk
Reference substance:
Composition 1
PBT status:
the substance is not PBT / vPvB
Justification:

Classification of 2,2,2-trichloro-1-phenylethyl acetatefor effects in the environment:

 

The chemical 2,2,2-trichloro-1-phenylethyl acetate (CAS no. 90-17-5) is used as an odor agent in perfumes. It is also used as a fixative for essential oils and perfumes etc. The aim was to assess whether the PBT criterion within Annex XIII was fulfilled for 2,2,2-trichloro-1-phenylethyl acetate.The PBT criterion was herein assessed based on experimental data in conjunction with standardized environmental fate models. Here follows a description of the PBT assessment.

 

Persistence assessment

The tested substance does not fulfil the P criterion within Annex XIII based on the assessment that here follows:

 

Biotic degradation

28-days Closed Bottle test following the OECD guideline 301 D was performed to determine the ready biodegradability of the test item. The study was performed at a temperature of 20°C. The test system included control, test item and reference item. Polyseed were used as inovulum. The concentration of test and reference item (Sodium Benzoate) chosen for both the study was 4 mg/L, while that of inoculum was 32ml/L. OECD mineral medium was used for the study. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % degradation was calculated using the values of BOD and ThOD for test item and reference item. The % degradation of procedure control (reference item) was also calculated using BOD & ThOD and was determined to be 79.51 %. Degradation of Sodium Benzoate exceeds 42.16 % on 7 days &  63.25 on 14th day. The activity of the inoculum is thus verified and the test can be considered as valid. The BOD28 value of test chemical was observed to be 1.8 mgO2/mg. ThOD was calculated as 1.25 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to Closed Bottle test was determined to be 76 %. Based on the results, the test item, under the test conditions, was considered to be readily biodegradable in nature.

 

Thus, based on the available information, it indicates that chemical 2,2,2-trichloro-1-phenylethyl acetate can be considered to be readily biodegradable in water and thus likely to be not persistent (not P) in nature.

 

Bioaccumulation assessment

The tested substance does not fulfil the B criterion within Annex XIII based on the assessment that here follows:

 

The estimated BCF value from modelling databases was evaluated to be 162.2 L/Kgand the octanol water partition coefficient of the test chemical was determined to be 3.535, which is less than the threshold of 4.5. If this chemical is released into the aquatic environment, there should be a low risk for the chemical to bioaccumulate in fish and food chains.

 

Toxicity assessment

The tested substance does not fulfil the T criterion within Annex XIII based on the assessment that here follows:

 

Mammals

The tested chemical is regarded to be not classified for carcinogenicity, mutagenicity and reprotoxicity, Further, there is no evidence of chronic toxicity, as identified by the classifications STOT (repeated exposure), category 1(oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume) or category 2 (oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume).

  

Aquatic organisms

All of the available short-term eco-toxicity data for fish, aq. invertebrate and algae for the substance2,2,2-trichloro-1-phenylethyl acetateindicates the LC50/EC50 value to be in the range 3.4 mg/l to 16.8 mg/L, respectively. These value suggest that the substance is likely to be hazardous to aquatic organisms at environmentally relevant concentrations. Since the test chemical 2,2,2-trichloro-1-phenylethyl acetate is readily biodegradable in nature, chemical 2,2,2-trichloro-1-phenylethyl acetate is likely to be not hazardous to aquatic organisms at environmentally relevant concentrations and can be considered to be ‘Not classified’ as per the CLP regulation.

 

On the basis ofthe estimated data oflong term eco-toxicity data for fish and aq. Invertebrates, the NOEC value was estimated to be ranges from 0.568 to 2.02 mg/l, respectively. These value suggest that the substance is likely to be hazardous to aquatic organisms at environmentally relevant concentrations and can be considered to be classified in ‘Aquatic chronic category 3’ as per the CLP regulation. By speculation, long-term NOEC for aquatic organisms were not expected for the substance at concentration below 0.01 mg/L based on the data mentioned above.

 

The chemical was therefore not considered as hazardous to aquatic environments as per the criteria set out in Annex XIII.

 

 

Conclusion

Based on critical, independent and collective evaluation of information summarized herein, the tested compound does not fulfil the P, B and T criterion and has therefore not been classified as a PBT compound within Annex XIII.