Registration Dossier
Registration Dossier
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EC number: 278-934-5 | CAS number: 78521-39-8
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 4.44
- Temp.:
- 20 °C
- Remarks on result:
- other: The SD of pKa ± 0.02
- Conclusions:
- The measured dissociation constant (pK) of ASC plus in water at 20.0 ± 1.0°C was 4.44.
- Executive summary:
The dissociation constant(s) of 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid were determined according to the OECD guideline 112 (Dissociation constant in water) by titration of a solution of the test item with 0.05 M sodium hydroxide. The test was conducted at 20.0 ± 1.0 °C and three replicates were performed. The measured dissociation constant (pK) was 4.44 ± 0.02.
Reference
The dissociation constant (pK) was calculated for chosen 10 points of the titration curve from the first interval in which the incereas of pH is negligible (the well buffered region).
The result is the mean value of 3 replicates.
Description of key information
The measured dissociation constant (pK) was 4.44.
Key value for chemical safety assessment
- pKa at 20°C:
- 4.44
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