Registration Dossier

Administrative data

Description of key information

Although no specific carcinogenicity study is available on alkyl ether sulfates (AES), the scientific weight of the evidence suggests that members of the AES category do not cause carcinogenic effects. This expert judgment takes account of the complete absence of genotoxicity and structural alerts for genotoxicity and carcinogenicity for all members of AES category as well as their overall low toxicity in repeated dose toxicity studies.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The alkyl ether sulfates (AES) reported within the category show similar structural, physico-chemical, environmental and toxicological properties. The approach of grouping different AES for the evaluation of their effects on human health and the environment was also made by the Danish EPA (2001) and HERA (2003), supporting the read-across approach between structurally related AES.

Several studies investigating the genetic toxicity of different AES in vitro and in vivo have shown that AES are not genotoxic. Moreover, the repeated dose toxicity tests revealed no substance-related adverse effects indicative for carcinogenicity such as preneoplastic lesions (e.g. hyperplasia or metaplasia). Furthermore, AES are metabolised to physiologically occurring metabolites, which chemically behave like in the same way as their natural counterparts. The systemic toxicity of the compounds in this category is predicted to be very low, based on the known properties of the predictable metabolites. Based on this weight of evidence approach members of the AES category does not cause carcinogenicity. In accordance to Regulation (EC) No. 1907/2006, Annex X, 8.9.1 Column 2, testing of carcinogenicity is not required.

Justification for classification or non-classification

Based on weight of evidence members of the AES category does not cause carcinogenicity. This endpoint is therefore considered to be conclusive but not sufficient for classification.