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EC number: 234-974-5
CAS number: 12047-11-9
Inhaled barium hexaferrite powder may induce pneumoconiosis (identified as critical effect) following repeated exposure at concentrations higher than 30 mg/m3 (NOAEC).
The repeated dose toxicity of barium hexaferrite was assessed by
inhalation route, the most relevant route of exposure for workers
exposed to the substance. According to Kosova et al (1972), barium
hexaferrite may cause fibrogenic activity in lungs inducing
pneumoconiosis at concentrations higher than 30 mg/m3. Another study
investigating the toxic effects caused by some ferrites powder is
available; however, it does not document exhaustively the study
conducted. The poor documentation does not allow to evaluate the
reliability of the test; in particular, it is characterized from the
- it is not clear if the analytical exposure concentrations are relative
to barium, as element, or to barium hexaferrite, as molecule.
- the available documentation does not allow to evaluate if the observed
effects have to be considered as toxic effects or as adaptive responses.
- the exposure time, which is of 24 hours/day, is unconventional and it
does not allow lung particles clearance, as it could occur in workers
professionally exposed 8 hours/day.
According to Regulation (EC) n. 1272/2008, study results indicate that
the substance has to be classified for organ target toxicity after
repeated dose, specifying lung as target organ and inhalation as
significant route (STOT RE Cat. 2 H373).
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