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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Barium hexaferrite shares common functional groups with iron oxides.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
No purity information is available (data from secondary source).

3. ANALOGUE APPROACH JUSTIFICATION
Both barium hexaferrite and iron oxides are water insoluble, powdered substances. In contact with eyes, in the clinical experience they behave similarly.

4. DATA MATRIX
Data drom secondary source. Detailed information is not avalilable.

Data source

Reference
Reference Type:
secondary source
Title:
Hazardtext - Iron oxide
Author:
TOMES System
Year:
2010
Bibliographic source:
TOMES System (electronic version). Thomson Reuters, Greenwood Village, Colorado, USA. Edition 2010.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
observation after clinical and practical experience
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vivo

Results
Irritation parameter:
other: clinical observations
Remarks:
clinical observations
Time point:
other: not declared
Remarks on result:
other: Iron oxides would be expected to be an eye irritant from frictional action.

Any other information on results incl. tables

Iron oxides would be expected to be an eye irritant from frictional action.

Applicant's summary and conclusion

Interpretation of results:
other: irritating effect related to frictional action
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
Barium hexaferrite powder may have eye irritating effects due to frictional action.
Executive summary:

Barium hexaferrite powder may have eye irritating effects due to frictional action.