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EC number: 234-974-5
CAS number: 12047-11-9
Both in vitro skin corrosion and skin irritation tests gave negative results. Moreover, in vivo studies mentioned in the medical Russian literature support the lack of skin irritating effects due to barium hexaferrite. Barium hexaferrite is not an eye irritant in vitro testing.
In vitro tests on skin corrosion/irritation have been conducted in
2010 according to validated methods; in addition an in vivo test (as
preliminary study of a guinea pig maximization test) was performed too.
All carried out tests gave negative results. In vivo further testing was
deemed not necessary at present, considering the coherence of available
experimental results with old in vivo Russian literature data
(Ermachencko, 1987) which document the lack of in vivo skin irritation.
In vitro test on eye irritation showed negative results. In vivo further
testing was deemed not necessary, as the frictional action of the powder
may significantly interfere with results, giving false positive
responses not related to the chemical action.
Read-across justification: experimental data obtained with barium
hexaferrite in in vitro eye irritation test, are evaluated together with
clinical observations coming from the practical experience with iron
oxide eye exposure. Indeed, both substances of interest are water
insoluble and rather inert (intended as non reactive in contact with
skin and mucous); it is deemed, in this context, that they can be
According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008,
study results indicate that the substance should not be classified
neither for skin corrosion/irritation nor for eye irritation.
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