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EC number: 234-974-5
CAS number: 12047-11-9
The barium hexaferrite is not adsorbed when it is administered by oral route.
An extensive literature search did not show
studies on barium hexaferrite toxicokinetics. However, because ferrites
absorption is controversial, it was chosen to assess barium hexaferrite
urinary elimination and the barium plasma concentration during the acute
toxicity study. The assessment of barium and iron urinary levels and the
barium plasma concentration, even if it is not mandatory according to
REACH requirements, was essential in order to solve the issue on
substance absorption from which depended the execution of other in vivo
tests (mutagenicity and toxicity to reproduction).
Considering the barium and the iron amount
recovered in urine and the barium concentration measured in plasma, it
can be concluded that the barium hexaferrite is not adsorbed by oral
It has to be noted that barium and iron in
urine do not reflect the stoichiometric ratio of these two elements in
barium hexaferrite. It cannot be excluded that a little amount of both
barium and iron can be present in the substance as non reacted
materials, available for systemic absorption. Since the solubility and
consequently the possible absorption rate is greater for barium oxide
than for iron oxide, this can explain the difference observed between
barium and iron urinary excretion (barium 0,04% and iron 0,01% of the
administered dose, respectively).
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