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EC number: 256-360-6
CAS number: 48145-04-6
Prior to use, the master strains were checked for characteristics,
viability and spontaneous reversion rate (all were found to be
satisfactory). The amino acid supplemented top agar and S9‑mix used in
both experiments was shown to be sterile. The culture density for each
bacterial strain was also checked and considered acceptable.
A history profile of vehicle, untreated and positive control
values for 2010 and 2011 was included in the test report. The results of
this study was in accordance with the history profile.
2-phenoxyethyl acrylate was tested in the reverse mutation assay (Ames
Test) using Salmonella Typhimurium strains (TA1535, TA1537, TA98,
TA100) and Escherichia Coli strain (WP2uvrA). The test was performed in
accordance with OECD test guideline 471 and EU B13/14 using the plate
incorporation and pre-incubation methods at five dose levels, in
triplicate, both with and without the addition of rat liver homogenate
metabolosing system (10% liver S9 in standard co-factors). The dose
range was determined in a preliminary toxicity assay and was 50 to 5000
ug/plate in the first experiment.The experiment was repeated on a
seperate day (pre-incubatrion method) using the same dose range, fresh
cultures of the bacterial strains and fresh 2 -phenoxyethyl acrylate
No toxicological significant increases in the frequecy of revertant
colonies were recorded for any of the bacterial strains, with any dose
of 2-phenoxyethyl acrylate, either with or without metabolic activation
per exposure method, hence 2-phenoxyethyl acrylate was found to be
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