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EC number: 256-360-6
CAS number: 48145-04-6
The dermal irritation of 2-phenoxyethyl acrylate was investigated in two studies, both showing no/slight irritation. A short term study (4 hours exposure) on dermal irritation found that 2-phenoxyethyl acrylate was not irritating. In the key study (24 hour exposure study with 72 hour follow up) sligth reversible irritation was observed,, dermal reactions were observed only in two out of six animals, and with the dermal irritation index of 0.25. The major criteria for a classification as skin irritant is therefor not met.The eye irritation of 2-phenoxyethyl acrylate was investigated in a rabbit study, showing light irrittion. The major criteria for a classification as eye irritant is therefore not met.
The skin irritation potential of 2-phenoxyethyl acrylate was
investigated on intact and abraded skin on rabbits. A single occlusive
application for 24 hours elicited very slight dermal irritation, in two
out of six animals. Primary irritation index was calculated to be 0.25.
and 2-phenoxyethyl acrylate is therefore not a skin irritant. Hence, no
classification is needed.
The eye irritation potential of 2 -phenoxyethyl acrylate were
investigated in rabbits following the draize test. The substance was
shown to be slightly irritating, but fully reversible after 48 hours.
The available experimental data suggest that 2-phenoxyethyl acrylate is
not corrosive, as all observed effects were fully reversible.
The key study on dermal irritation found that only two of six animal had
dermal reactions, leading to a primary irritation index of 0.25. The
major criteria for classification as irritant is therefore not met ( at
least two of three animals, with a mean score between 2.3 to 4.0).
Supplementary information from another non-GLP skin irritation study in
rabbits (BASF_1982) showed reactions to intact and abreaded skin. After
8 days, erythema (score 2; max score 3) was not reversible in 2/6
animals on intact skin. In contrast, edema (score 1.6; max score 3) was
fully reversible after 8 days in all animals. For erythema (score 2.5;
max score 3) was not fully reversible on abreaded skin after 8 days
The data from the study available on eye irritation (BASF_1981) shows
that all animals have ligth redness, score 1, which is fully reversible
after 48 hours, where only one animal show ligthly increased redness.
Supplementary information from another non-GLP eye irritation study in
rabbits (BASF_1982) shows a max conjunctivae scores of 1 (medium of
0.39) which was fully reversible within the observation period.
Justification for selection of skin irritation / corrosion
This is the most recent study, performed according to GLP, and of
longer duration than the study from 1994
Justification for selection of eye irritation endpoint:
The only study available on eye irritation
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
A short term study (4 hours exposure) on dermal irritation found that
2-phenoxyethyl acrylate was not irritating. In the key study (24 hour
exposure study with 72 hour follow up) sligth reversible irritation was
observed,, dermal reactions were observed only in two out of six
animals, and with the dermal irritation index of 0.25. The major
criteria for a classification as skin irritant is therefor not met.
For classification as an eye irritant the criteria are also not met, as
reactions observed were fully reversible, and mean scores following
grading 24, 48, and 72 hours were lower than the criteria set in table
3.3.2 in Regulation (ec) 1272/2008.
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