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EC number: 256-360-6
CAS number: 48145-04-6
No inhalation study available. Thus, extrapolation from 90D oral study
wtih a NOAEL of 350 mg/kg bw/d with respect to repeated dose toxicity.
value as a starting point for chronic DNEL derivation for workers with
respect to dermal and inhalational exposure:
of dose metric to inhalational concentration:
R.8 guidance uses an inhalation volume for rats of 0.38 m3/kg for 8 hr
to NOAEC conversion:
= 350 mg/kg/d / 0.38 m3/kg = 921 mg/m3
As no data
is available for absorption rate for oral exposure versus inhalation
exposure a default factor of 2 is used for accounting for the potential
for higher absorption by inhalation :
= 921 mg/m3 / 2 = 461 mg/m3
Correction factor for increased inhalation volume during work:
NOAEC worker, 8hr = 6.7 m3/ 10m3 x 461 mg/m3 = 309 mg/m3
2-phenoxyethyl acrylate has low acute toxicity (oral and dermal). No
data for the acute inhalational toxicity is available. Results from
irritation studies (skin and eye) indicates a no to low potential. The
substance has been shown to be a sensitizer in a Guinea pig maximisation
test and should therefore accordingly be classified as Skin. Sens. 1A.
Based on the data from an OECD 422 study (conducted in 2012/2013), a
NOAEL of 300 mg/kg bw/day for systemic repeated dose toxicity is
concluded. Further, a NOAEL of 800 mg/kg bw/day (male) and 300 mg/kg
bw/day (female, based on post implantation losses) for reproductive
toxicity was concluded.
Exposure of 2-phenoxyethyl acrylate to humans is only relevant for
workers in industrial processing and professional uses. Based on the
physical/chemical properties, dermal absorption is considered the most
relevant exposure route. DNEL for systemic effect of 3.5 mg/kg bw/day
has been derived based on a NOAEL of 350 mg/kg bw/day for sytemoc
effects in relation to repeated dose toxicity in a OECD 408 study (90D
oral exposure). This DNEL value is considered conservative as dermal
absorption is considered equal to oral absorption. No DNEL for skin
sensitising effects can be derived, thus dermal exposure is considered
most critical route of exposure.
Based on the NOAEL of 350 mg/kg/bw /day from oral exposure, a DNEL for
inhalation of 12 mg/m3 was derived by route-to-route extrapolation for
protection against any systemic effects.
As hydrolysis of 2-phenoxyethyl acrylate into acrylic acid and
2-phenoxyethanol may occur, there is a potential of local toxicity in
the lung due to the formation of acrylic acid. In 2012, SCOEL derived an
OEL value of 10 ppm (29 mg/m3) for acrylic acid. 10 ppm of 2
-phenoxyethyl acrylate equivalates to 77 mg/m3. This worst case and
indicative DNEL value for local effects is less restrictive than the
DNEL for systemic effects (10 mg/m3).
Exposure of consumers/general population to 2-phenoxyethyl acrylate is
not relevant as only used in industrial settings and professional uses.
Therefore, no hazard identification for consumers/general population
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