Registration Dossier
Registration Dossier
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EC number: 203-714-2 | CAS number: 109-87-5
Endpoint summary
Administrative data
Description of key information
Methylal has been considered a slight irritant to the skin of the rabbit with a calculated Primary Irritation Index of 0.42 (Rush, 1989). Myers (1982) concluded that methylal was not irritating when applied at 0.5 ml on rabbit skin. but methylal is not irritating according to CLP Regulation.
No key value was considered for eye irritation because no evaluation criteria of results was given by Myers (1982).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Slightly irritating for skin irritation/corrosion was retained (instead of not irritating) because evaluation criteria have been presented in the test of Rush (1989) and not in the assay of Myers (1982).
Myers (1982) concluded that application of 0.1 and 0.01 mL of methylal per rabbit eye induced minor to moderate eye irritation and mild transient conjunctival irritation, respectively but evaluation criteria of results was given.
Respiratory irritation assay was not performed.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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