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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 18 February 2016 to 30 March 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling Point)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
method according to Siwoloboff
Specific details on test material used for the study:
- Analytical purity: 92%
- Expiration date of the lot/batch: 13.10.2017
Key result
Boiling pt.:
>= 273.9 - <= 277.7 °C
Atm. press.:
>= 1 006 - <= 1 011 hPa
Remarks on result:
other: ± 1.1 °C

Table 1. The observed values of boiling point of Propionic acid,,2’’ - [(vinylsilylidyne) trioxy] tri-, triethyl ester

Sample

Visually

Automatically

Atmospheric pressure, hPa

Boiling point, °C

1

273.9

277.7

1006

2

274.6

276.5

1011

3

274.2

275.6

1011

Average values ± standard deviations, °C

274.2 ± 0.4

276.5 ± 1.1

-

Table 2: Calibration and verification of readings of a BÜCHI M-565 apparatus

Calibration

Standard name

Boiling point of standard according to certificate, °C

Measured boiling point of standard, °C

Pharmacopeia mode

Automatically (Pharmacopeia mode)

1.

4-Nitrotoluene

52.4± 0.2

52.5± 0.03

2.

Diphenylacetic Acid

147.5 ± 0.2

147.8. ± 0.14

3.

Caffeine

236.7 ± 0.2

236.7 ± 0.16

4

Potassium Nitrate

334.6 ± 0.2

334.4 ± 0.16

Verification

 

Standard name

Boiling point of standard according to certificate, °C

Measured boiling point of standard, °C

Pharmacopeia mode

Automatically (Pharmacopeia mode)

1.

Benzil

95.1 ± 0.2

95.3 ± 0.05

2.

p-Anisis Acid

184.2 ± 0.2

184.1.± 0.06

3.

Phenolphthalein

261.6 ± 0.2

260.7.± 0.17

Conclusions:
The boiling point of the test substance is in the temperature range of 273.9 - 277.7 ºC ± 1.1 °C.
Executive summary:

The boiling point of the test substance was determined in accordance with the OECD Guideline 103 with GLP. The method according to Siwoloboff was used. A preliminary study was carried out in order to determine the boiling temperature range. During the main study three readings were carried out visually and automatically. The boiling point of the test substance is in the temperature range of 273.9 - 277.7 ºC ± 1.1 °C.

Description of key information

Key study: According to OECD Guideline 103. GLP study.  The boiling point of the test substance is in the temperature range of 273.9 - 277.7 ºC ± 1.1 °C.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
273.9 °C

Additional information