Registration Dossier
Registration Dossier
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EC number: 701-199-3 | CAS number: -
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Based on the available study, aluminium potassium fluoride does not induce sensory irritation in the respiratory tract.
Additional information
The airway irritating properties of aluminium potassium fluoride were studied by exposing three groups of four male mice to test atmospheres containing the substance at concentrations of 283, 592 and 604 mg/m3 for a single period of 20, 20 and 30 minutes, respectively (TNO, 1999b).
A decrease in breathing rate or post-inspiratory apnoea were not seen in the breathing pattern. During exposure, no changes in behaviour were seen. No abnormalities or clinical signs were seen during the 7-day observation period. None of the mice died. Dose (exposure*time) related weight decrease was not observed. Abnormalities at necropsy consisted primarily of discoloured areas on the lungs to a varying extent in the highest concentration group.
From the results of the present study in mice, it was concluded that a sensory irritation response of inhalable particles of aluminium potassium fluoride at the technically highest attainable concentration under the conditions of this study (604 mg/m3) was not found.
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