Registration Dossier
Registration Dossier
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EC number: 615-206-1 | CAS number: 709031-45-8
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 24 Oct 2017 to 27 Jan 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Since the substance was expected to be miscible with water, a solubility test was performed first. After stirring the test item with water, the mixture was checked visually for any undissolved test material. Additionally, the water phase was analysed (cation). Based on the result (miscible with water) it was concluded that no guideline method (flask or column elution) needs to be conducted.
- GLP compliance:
- yes
- Type of method:
- other: miscibility test
Test material
- Reference substance name:
- (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide
- EC Number:
- 615-206-1
- Cas Number:
- 709031-45-8
- Molecular formula:
- C6H10N2O.CH4O3S
- IUPAC Name:
- (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide
- Test material form:
- solid
- Details on test material:
- - Appearance: Light tan solid
- Storage conditions: At room temperature protected from light
Constituent 1
- Specific details on test material used for the study:
- All solutions containing the test item were protected from light.
Results and discussion
Water solubility
- Key result
- Water solubility:
- > 1 000 g/L
- Temp.:
- 20 °C
- pH:
- 2.3
- Remarks on result:
- completely miscible
- Details on results:
- After the stirring period, the test sample was clear and no undissolved test item was observed.
The content of cationic part of test item that was dissolved in water sample was 673 g/L.
Any other information on results incl. tables
Testing above 1000 g/L is technically not feasible.
Applicant's summary and conclusion
- Conclusions:
- The substance is completely miscible with water at 20°C . The water solubility at 20°C was concluded to be > 1000 g/L.
- Executive summary:
In a GLP experiment, it was observed visually that the substance is completely miscible with water at a nominal concentration of 1220 g/L at 20°C and pH 2.3. The water solubility at 20°C was concluded to be > 1000 g/L. The content of cationic part of test item that was dissolved in water sample was 673 g/L.
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