Registration Dossier
Registration Dossier
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EC number: 814-308-5 | CAS number: 63286-42-0
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study performed under GLP. All relevant validity criteria were met.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected: September 2015; signature: November 2015
- Type of method:
- differential scanning calorimetry
- Melting / freezing pt.:
- -8.8 °C
- Atm. press.:
- ca. 1 004 hPa
- Decomposition:
- no
- Sublimation:
- no
- Remarks on result:
- other: mean melting point (n=3); measurement under flow of nitrogen
- Conclusions:
- The melting temperature of the test item has been determined to be -8.8 ± 0.5 °C (or 264.4 ± 0.5 K). At this temperature the substance is considered to be liquid.
- Executive summary:
The melting temperature was determined using OECD TG 102 and EU Method A.1 with the Differential Scanning Calorimetry method under GLP. The guideline defines the melting temperature as: the temperature at which the phase transition from solid to liquid state occurs at atmospheric pressure and this temperature ideally corresponds to the freezing temperature. The melting temperature of the test item were determined as the mean melting temperature obtained from three experiments; from which the thermal events for each individual DSC-runs were within ± 0.5°C of the determined mean. The mean melting point was -8.8 ± 0.5 °C (264.4 ± 0.5 K). At this temperature the substance is considered to be liquid.
Reference
Main study
- Experiment 1: During cooling an exothermic peak (crystallisation) was observed between -40°C and -80°C (results are archived in the raw data). During heating an exothermic followed by an endothermic and exothermic peak was observed between -75°C and -25°C. The effects were most likely obtained due to melting with cold crystallisation. An endothermic peak between -25°C and 25°C was observed. The extrapolated onset temperature of the peak was -8.574°C. The endothermic effect was most likely obtained due to melting of the test item.
- Experiment 2: A duplicate DSC was performed to determine the duplicate melting and boiling temperatures of the test item. A lower cooling rate of -1°C/minute and a higher heating rate of 50°C/minute was used from 25°C with more test item. The endothermic peak extrapolated onset of the melting peak was -8.510°C.
- Experiment 3: Using conditions similar to Experiment 2, the endothermic peak extrapolated onset of the melting peak was -9.260°C.
Applicant assessment indicates: The melting temperature of the test item were determined as the average melting temperature obtained from Experiment 1, Experiment 2 and Experiment 3. The individual results were within ±0.5°C of the mean determination of the all three runs (n=3). The highest temperature thermal event in the melting point determination was mean -8.8 °C. At this temperature the substance is liquid.
Description of key information
Mp: -8.8 ± 0.5 °C (264.4 ± 0.5 K) at 1 atmosphere, OECD TG 102 - DSC Method, 2017
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- -8.8 °C
Additional information
The melting temperature was determined using OECD TG 102 and EU Method A.1 with the Differential Scanning Calorimetry method under GLP. The guideline defines the melting temperature as: the temperature at which the phase transition from solid to liquid state occurs at atmospheric pressure and this temperature ideally corresponds to the freezing temperature. The melting temperature of the test item were determined as the mean melting temperature obtained from three experiments; from which the thermal events for each individual DSC-runs were within ± 0.5°C of the determined mean. The mean melting point was -8.8 ± 0.5 °C (264.4 ± 0.5 K). At this temperature the substance is considered to be liquid..
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