Registration Dossier
Registration Dossier
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EC number: 251-889-9 | CAS number: 34231-26-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- BASF-Testing method
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-amino-4-hydroxy-2-[(6-hydroxyhexyl)oxy]anthraquinone
- EC Number:
- 251-889-9
- EC Name:
- 1-amino-4-hydroxy-2-[(6-hydroxyhexyl)oxy]anthraquinone
- Cas Number:
- 34231-26-0
- Molecular formula:
- C20H21NO5
- IUPAC Name:
- 1-amino-4-hydroxy-2-[(6-hydroxyhexyl)oxy]-9,10-dihydroanthracene-9,10-dione
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- Back: 1, 5, 15 minutes; 20 hours
Ear: 20 hours - Observation period:
- 24 hours, 8 days
- Number of animals:
- no data
- Details on study design:
- TEST SITE
- Area of exposure: back and ear
- % coverage: -
- Type of wrap if used: -
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Slight irritating effects were found on on scarcified skin, after 7 days no irritation was observed anymore. On intact skin, no effects were determined.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance did not cause any signficant signs of irritation on rabbit skin. The substance is not classifiable.
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