Registration Dossier

Administrative data

Description of key information

2017 LLNA  pre-test: The observations in the OECD 429 LLNA pretests are indicative of the substances being corrosive.

Scores of =/> 3 were observed at concentrations 50, 25 and 10%

Ear swelling was greater than 25% at 25 and 50%

Body weight loss (>5%) was observed possibly indicative of systemic toxicity.

The main argument for not continuing with the main LLNA studies is the interpretation of the study director with regard to eschar formation at all concentrations tested on day 6.

Based on this observation, and in light of experience with the substance it was decided to apply a precautionary labelling of Corrosive 1C to Hydroxypropyl, 2-, trimethylammonium formate.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification