Registration Dossier
Registration Dossier
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EC number: 617-180-7 | CAS number: 80875-98-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- Test performed according to OECD of 12/05/1981
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline of 12/05/1981
- Principles of method if other than guideline:
- Single exposure of 500mg of the substance on 6cm2 of closely cropped skin of 6 rabbits.
Continuous contact during 4 hours by means of semi occlusive plaster
Cutaneaous effects observed 1 hour after plaster take off then, daily observation (3 to 14 days) - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid
- EC Number:
- 617-180-7
- Cas Number:
- 80875-98-5
- Molecular formula:
- C9 H15 N O2
- IUPAC Name:
- (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- Cream to white powder
Constituent 1
- Specific details on test material used for the study:
- OP 1/87 SI
In vitro test system
- Test system:
- other: rabbits
- Source species:
- rabbit
- Source strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Amount/concentration applied:
- Single exposure of 500mg of the substance on 6cm2 of closely cropped skin of 6 rabbits
- Duration of treatment / exposure:
- 4 hours
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- Single exposure of 500mg of the substance on 6cm2 of closely cropped skin of 6 rabbits
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: rash
- Run / experiment:
- 72 hours
- Value:
- ca. 0
- Irritation / corrosion parameter:
- other: oedema
- Run / experiment:
- 72 hours
- Value:
- ca. 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No cutaneaous effects --> 9490 PERHYDROACIDE is non irritant or corrosive
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