4,7-Decanediol, 2,4,7,9-tetramethyl-

Biotransformation and kinetics

Administrative data

Endpoint:

biotransformation and kinetics

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: according to EC Directive 92/69/EEC and Regulation EC/440/2008 guideline methods under GLP conditions This data is valid as documented CCRF for this category (Acetylenic geminalic diols)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD 301 B, 92/93/EEC, C.4-C

Deviations:

no

GLP compliance:

yes

Type of medium:

aquatic

Test material

Test material information

Constituent 1

Reference substance name:

2,4,7,9-tetramethyldec-5-yne-4,7-diol

EC Number:

204-809-1

EC Name:

2,4,7,9-tetramethyldec-5-yne-4,7-diol

Cas Number:

126-86-3

Molecular formula:

C14H26O2

IUPAC Name:

2,4,7,9-tetramethyldec-5-yne-4,7-diol

Details on test material:

Batch-#: 11029
Purity: 98.3 %

Results and discussion

Transformation products:

not measured

Applicant's summary and conclusion

Conclusions:

2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol was not readily biodegradable under the conditions of the modified Sturm test presently performed. Approximately 5 percent degraded in 28 days.

Executive summary:

2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol was not readily biodegradable under the conditions of the modified Sturm test presently performed. Approximately 5 percent degraded in 28 days. 2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol was tested for its ready biodegradability in the carbon dioxide (CO2) evolution test (modified Sturm test) at 36.3 ml per 2 litres, corresponding with 12 mg TOC/l. The Theoretical CO2 production (ThCO2) of 2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol was calculated to be 2.72 mg CO2/mg, corresponding with 2.42 mg CO2/ml. The relative degradation values calculated from the measurements performed during the test period revealed no significant degradation of 2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol. In the toxicity control of 2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol was found to be not inhibitory. Since all acceptability criteria prescribed by the protocol were met, this study was considered to be valid.