Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD Guideline 105
- Deviations:
- yes
- Remarks:
- OECD Guideline 105 is a water solubility test. To determine the solubility of the substance in octanol, a similar protocol was used using octanol as the solvent.
- GLP compliance:
- not specified
Test material
- Test material form:
- solid: flakes
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Mitsubishi-Chemical Food Corporation;
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: in refrigerator
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: pulverized
Results and discussion
Solubility in organic solvents / fat solubility
- Key result
- Medium:
- n-octanol
- Solubility:
- >= 1 000 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: miscible in octanol
- Test substance stable:
- not determined
- Details on results:
- The pre-test solubility was incorrect as the test substance dissolution kinetics were slower than foreseen.
No precipitation was seen even after 10 g of test substance had been added. The solution became very viscous and could no longer be stirred.
Applicant's summary and conclusion
- Conclusions:
- The test substance is completely miscible in octanol.
- Executive summary:
The solubility of the test substance was determined in a study performed similarly to a OECD Guideline 105 water solubility study, but octanol was used as the solvent. Up to 10 g of test substance was added to 10 mL of water. The liquid became very viscous, but no precipitate was observed. The solubility of the test substance in octanol is at least 1 kg/L octanol. The test substance is completely miscible in octanol at 20 degrees C.
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