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EC number: 210-073-2 | CAS number: 604-68-2
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 - 18 May 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- α-D-glucose pentaacetate
- EC Number:
- 210-073-2
- EC Name:
- α-D-glucose pentaacetate
- Cas Number:
- 604-68-2
- Molecular formula:
- C16H22O11
- IUPAC Name:
- 1,2,3,4,6-penta-O-acetyl-alpha-D-glucopyranose
- Reference substance name:
- β-D-glucose pentaacetate
- EC Number:
- 210-074-8
- EC Name:
- β-D-glucose pentaacetate
- Cas Number:
- 604-69-3
- Molecular formula:
- C16H22O11
- IUPAC Name:
- 1,2,3,4,6-penta-O-acetyl-beta-D-glucopyranose
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Oxidane
- Reference substance name:
- Unknown impurities.
- Molecular formula:
- Not available as unknown impurities.
- IUPAC Name:
- Unknown impurities.
- Test material form:
- solid: crystalline
- Remarks:
- Crystalline powder
- Details on test material:
- Batch No: 14126200
Storage: at room temperature, protected from light
Constituent 1
impurity 1
impurity 2
impurity 3
- Specific details on test material used for the study:
- Since the test item contains no lager particles, sieving < 2000 µm was not necessary and the test item was used as delivered.
Results and discussion
Particle sizeopen allclose all
- Key result
- Percentile:
- D10
- Mean:
- 1.2 µm
- St. dev.:
- 0.012
- Remarks on result:
- other: Average result calculated from the results of two test series
- Key result
- Percentile:
- D50
- Mean:
- 10.9 µm
- St. dev.:
- 0.023
- Remarks on result:
- other: Average result calculated from the results of two test series
- Key result
- Percentile:
- D90
- Mean:
- 205.7 µm
- St. dev.:
- 1.554
- Remarks on result:
- other: Average result calculated from the results of two test series
Any other information on results incl. tables
Visual Microscope Analysis
(1) under a microscope with 5x magnification only agglomerates can be observed, the shape of particles was not recognizable.
(2) under a microscope with 20x magnification only agglomerates can be observed, the shape of particles was not recognizable.
(3) under a microscope with 50x magnification only agglomerates can be observed, the shape of particles was not recognizable.
Particle Size Distribution
The test item shows a bimodal particle size distribution with two peaks at approx. 7 µm and 200 µm.
Test series 1:
| Percentile | Particle size (µm) | Standard deviation |
| D10 | 1.2 | 0.01 |
| D50 | 10.9 | 0.148 |
| D90 | 207.2 | 2.792 |
Test series 2:
| Percentile | Particle size (µm) | Standard deviation |
| D10 | 1.2 | 0.015 |
| D50 | 10.9 | 0.243 |
| D90 | 204.1 | 3.753 |
Applicant's summary and conclusion
- Conclusions:
- The test item alpha-D-glucose pentaacetate (CAS 604-68-2) has a median particle size D50 = 11 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).
- Executive summary:
The test item alpha-D-glucose pentaacetate (CAS 604-68-2) has a median particle size D50= 11 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).
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