α-D-glucose pentaacetate

Stability: thermal, sunlight, metals

Administrative data

Endpoint:

thermal stability

Type of information:

experimental study

Adequacy of study:

key study

Study period:

9 - 11 May 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)

Version / remarks:

1981

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

α-D-glucose pentaacetate

EC Number:

210-073-2

EC Name:

α-D-glucose pentaacetate

Cas Number:

604-68-2

Molecular formula:

C16H22O11

IUPAC Name:

1,2,3,4,6-penta-O-acetyl-alpha-D-glucopyranose

impurity 1

Reference substance name:

β-D-glucose pentaacetate

EC Number:

210-074-8

EC Name:

β-D-glucose pentaacetate

Cas Number:

604-69-3

Molecular formula:

C16H22O11

IUPAC Name:

1,2,3,4,6-penta-O-acetyl-beta-D-glucopyranose

impurity 2

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

impurity 3

Reference substance name:

Unknown impurities.

Molecular formula:

Not available as unknown impurities.

IUPAC Name:

Unknown impurities.

Test material form:

solid: crystalline

Remarks:

Crystalline powder

Details on test material:

Batch No: 14126200
Storage: at room temperature, protected from light

Results and discussion

For thermal stability study

Test substance thermally stable:

yes

Operating temperature

Operating temperature 1

Key result

Operating temp.:

>= 80 - <= 120 °C

Remarks on result:

other: endothermic effect

Remarks:

test conducted in closed glass crucibles

Operating temperature 2

Key result

Operating temp.:

>= 260 - <= 350 °C

Remarks on result:

other: exothermic effect

Remarks:

test conducted in closed glass crucibles

Operating temperature 3

Key result

Operating temp.:

>= 80 - <= 120 °C

Remarks on result:

other: endothermic effect

Remarks:

test conducted in closed gold plated stainless steel crucibles

Operating temperature 4

Key result

Operating temp.:

>= 270 - <= 390 °C

Remarks on result:

other: exothermic effect

Remarks:

test conducted in closed gold plated stainless steel crucibles

Sublimation:

not determined

Transformation products:

not specified

Any other information on results incl. tables

Test conducted in closed glass crucibles:

In the temperature range of 80 – 120 °C an endothermic effect can be observed. In the temperature range of 260 – 350 °C an exothermic effect was detected, with a decomposition energy of <-210 J/g. Due to the fact that a pressure rise occurred at 350 °C, the exothermic effect was cut at 350 °C.

Test conducted in closed gold plated stainless steel crucibles:

In the temperature range of 80 - 120 °C an endothermic effect can be observed. In the temperature range of 270 - 390 °C an exothermic effect was detected, with a decomposition energy of -280 J/g.

Applicant's summary and conclusion

Conclusions:

The test item Alpha-D-glucose pentaacetate (CAS no. 604-68-2) showed an exothermic effect in the temperature range of 260 – 390 °C with a maximum decomposition energy of -280 J/g.

Executive summary:

The test item Alpha-D-glucose pentaacetate (CAS no.604-68-2) showed an exothermic effect in the temperature range of 260 – 390 °C with a maximum decomposition energy of -280 J/g.