Registration Dossier
Registration Dossier
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EC number: 228-630-3 | CAS number: 6310-09-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 1-(5-chloro-2-thienyl)ethan-1-one
- EC Number:
- 228-630-3
- EC Name:
- 1-(5-chloro-2-thienyl)ethan-1-one
- Cas Number:
- 6310-09-4
- Molecular formula:
- C6H5ClOS
- IUPAC Name:
- 1-(5-chlorothiophen-2-yl)ethan-1-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Doses:
- 10 mL/kg w/w
- No. of animals per sex per dose:
- 2000 mg/kg => 3 female rats
300 mg/kg => 3 female rats
50 mg/kg => 3 female rats
5 mg/kg => 6 female rats - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 25 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- H300 Fatal if swallowed
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