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EC number: 202-338-6
CAS number: 94-49-5
When tested up to and including 25%,
Ethylene glycol dibenzoate did not elicit an SI ≥ 3 and was therefore
not considered to be a skin sensitizer. It was established that the EC3
value exceeds 25%. The test substance is not classified for skin
Results of the pre-screen test:
At a 25% test item concentration no signs of systemic toxicity were
noted and no erythema was observed. At a 50% test item concentration
hunched posture was noted for both animals on Days 2 and 3 and slight
erythema was noted for one of the animals on Day 2.
Test item remnants were present on the dorsal surface of the ears of all
animals (between Days 1 and 6), which did not hamper scoring of the skin
Variations in ear thickness during the observation period were less than
25% from Day 1 pre-dose values.
Based on the tolerability of the test item, the highest test item
concentration selected for the main study was a 25% concentration.
Based on the outcome of the available study
the substance is not classifed as a skin sensitizer.
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