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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental starting date: 17 July 2017. Experimental completion date: 23 August 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Identification: Ethylglycol dibenzoate CAS 94-49-5
Description off-white solid flakes
Batch number: 10000005282
Purity 99.4%
Expiry date: 31 December 2021
Storage conditions room temperature, in the dark
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.75
Temp.:
30 °C
pH:
7.7
Key result
Type:
Pow
Partition coefficient:
5 600
Temp.:
30 °C
pH:
7.7
Details on results:
Preliminary Estimate
The log10 Pow was calculated to be 3.31.

Discussion
The result from the preliminary test indicated that the HPLC method was suitable for determination of partition coefficient for this test item.
The individual results for the sample did not vary by more than 0.1 log units as required by the test guidelines.

Partition coefficient of sample

The retention times, capacity factor and log10 Pow value determined for the sample are shown in the following table:

Injection Retention Time (min) Capacity Factor (K') Log10 K' Log10 Pow Mean Log10 Pow
1 11.331 5.64 0.752 3.75 3.75
2 11.336 5.64 0.752 3.75

Mean Log10 Pow: 3.75

Mean partition coefficient: 5.60 x 103

Conclusions:
The partition coefficient of the test item has been determined to be 5.60E3, log10 Pow of 3.75.
Executive summary:

Partition Coefficient (n-Octanol/Water). 5.60 x 103, Log10 Pow 3.75, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.

Description of key information

The measured log Kow is 3.75

Key value for chemical safety assessment

Log Kow (Log Pow):
3.75
at the temperature of:
30 °C

Additional information