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EC number: 276-127-2 | CAS number: 71873-51-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From December 30th, 2017 to January 12th, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- adopted: 27 July 1995
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 55.13 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 - 72
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- The solubility of the test item in milli-Q water was determined to be 55.12 g/l, 55.11 g/l and 55.17 g/l for replicates Flask 1 (24 Hours), Flask 2 (48 Hours) and Flask 3 (72 Hours) respectively. The mean water solubility resulted to be 55.13 g/l at 20 °C, with 0.06 % RSD and within the limit of 15 % for three time points.
- Conclusions:
- 55.13 g/l at 20 °C and pH 7.0
- Executive summary:
The water solubility of test item was determined in acordance with the OECD guideline 105 and United States Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances (TS-7101), Product Properties Test Guidelines, OPPTS 830.7840, EPA 712-C-98-041 March 1998. The analytical method was validated in accordance with SANCO/3029/99, rev 4.0 dated 11/07/00. The parameters such as specificity, linearity, accuracy and precision were verified during validation of the HPLC-UV method validation.
During the preliminary test, the test item solubility resulted to be more than 10-2 g/l, thus the shake flask method was chosen for the definitive test , which was performed in milli-Q water and under laboratory temperature condition of 20 °C. The samples were analyzed for test item concentration by high performance liquid chromatography and the solubility of test item was determined to be 55.13 g/l at 20 °C and pH 7.0.
Conclusion
55.13 g/l at 20 °C and pH 7.0
Reference
Day | Test item content (g/l) | pH |
24 hours | 55.12 | 7.0 |
48 hours | 55.11 | 7.0 |
72 hours | 55.17 | 7.0 |
Average | 55.13 | |
SD | 0.032 | |
% RSD | 0.06 |
Description of key information
55.13 g/l at 20 °C and pH 7.0
Key value for chemical safety assessment
- Water solubility:
- 55.13 g/L
- at the temperature of:
- 20 °C
Additional information
OECD 105 - Shake flask method
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