Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
37 days
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Batch 135214 of Disperse Blue 359 was a dark blue powder with a purity of 99%.
Analytical method:
other: Shake flask method
Key result
Type:
log Pow
Partition coefficient:
> 2.4
Temp.:
20 °C
pH:
ca. 7
Type:
Pow
Partition coefficient:
> 250
Temp.:
20 °C
pH:
ca. 7
Details on results:
The analysed concentration of the stock solution was 0.00865 g/L. Based on this the nominal quantity of the test item in the test samples was 0.0173 mg. The recoveries were determined according to this value.
The log Pow values were not within the criterion range of ± 0.3 log units, i.e. 0.4 log units. Since the difference was relatively small and the obtained values were not specific, it was considered to have no impact on the outcome of the study. Based on this, the Pow and logPow of the test item is given ad the mean value of all measurements.
No test item was detected in the pretreated samples from the blank mixture
Conclusions:
Partition coefficient was determined via the shake flask method at a pH of 7.
The Pow value of the test item at 20°C was > 250 which corresponds to a logPow value of >2.4
Executive summary:

Partition coefficient was determined via the shake flask method at a pH of 7.

The Pow value of the test item at 20°C was > 250 which corresponds to a logPow value of >2.4

Description of key information

Partition coefficient was determined via the shake flask method at a pH of 7.

The Pow value of the test item at 20°C was > 250 which corresponds to a logPow value of >2.4

Key value for chemical safety assessment

Log Kow (Log Pow):
2.4
at the temperature of:
20 °C

Additional information