Registration Dossier
Registration Dossier
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EC number: 203-003-7 | CAS number: 102-07-8
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 May 2017 to 23 Aug 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
Test material
- Reference substance name:
- 1,3-diphenylurea
- EC Number:
- 203-003-7
- EC Name:
- 1,3-diphenylurea
- Cas Number:
- 102-07-8
- Molecular formula:
- C13H12N2O
- IUPAC Name:
- 1,3-diphenylurea
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
White or off-white solid
Batch: 506001
Purity/Composition: 98%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
Test item storage: At room temperature
Stable under storage conditions until: 24 March 2018 (retest date)
Results and discussion
Water solubility
- Key result
- Water solubility:
- 2.55 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 7.2
- Remarks on result:
- other: Mean of the concentrations obtained at both flow rates
- Details on results:
- The coefficient of variation (CV) (n = 10) was ≤ 30% at both flow rates. It demonstrated that the system was equilibrated at all flow rates.
The maximum difference (MD) on the mean values of the samples at both flow rates was also ≤ 30%. Based on this, the water solubility of the test item is given as the mean value of these measurements.
The turbidity of the eluates was < 0.2 NTU. According to this, no undissolved particles were detected in the eluates.
Applicant's summary and conclusion
- Conclusions:
- This study validly assessed the solubility in water according to the specificied guidelines.The water solubility of the test item at 20°C was 2.55 mg/L.
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