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EC number: 701-122-3
CAS number: 106185-75-5
Individual values of skin reactions
Over 24-48-72 h
/ : no reading
The dermal irritation study was conducted
according to OECD guideline 404 in compliance with GLP. Three healthy
adult New Zealand white rabbits were exposed to 0.5 mL/rabbit of the
test item on clipped skin from the dorsal area for 4 hours in
semi-occlusive conditions. Skin reactions were observed at 1, 24, 48 and
72 h after removal of the substance until the disappearance of the
effects (day 7).1 hour after patch removal there was slight to well
defined erythema and oedema in all animals. Mean individual scores were
1.3, 1.0 and 0.3 for erythma and 1.0, 1.3 and 1.3 for oedema. The
reactions were reversible within 5 days (D6) for two animals and 6 days
(D7) for the third rabbit.
Therefore, the test item should not be
classified as irritating to the skin according to the criteria of
directive n°67/548/EEC and CLP regulation (EC) n°1272/2008.
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