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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
September 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted according to OECD 104 and EU A.4 guidelines, under GLP without deviation and with certificate of analysis included.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Key result
Temp.:
20 °C
Vapour pressure:
ca. 0.017 Pa

The measured values for temperature and vapour pressure are evaluated as follows: a graph with log p vs 1/T is plotted. Since these values are correlated by a linear relation, the data can be fitted to a linear graph. Slope and intercept of the regression as well as the regression coefficient r are stated.

Parameters of linear regression

Parameter

Value

Slope

-6882.77

Intercept

21.71

Correlation Coefficient r

1.0000

Coefficient of Determination r2

1.0000

 

Using the effusion method, two temperatures 30°C and 45°C were examined. The following vapour pressure were found:

1.03 *10-1 Pa at 30°C (standard deviation 9.11 * 10-3)

1.21 Pa at 45°C (standard deviation 6.47 * 10-2)

Using linear regression, the following vapour pressures for 20°C and 25°C were estimated:

1.71 * 10-2 Pa at 20°C

4.24 * 10-2 Pa at 25°C

The following vapour pressures were determined experimentally and considered as valid (mean and standard deviation given):

Experimentally Determined Vapour Pressures

T

T

P

Stand. Dev. P

RSD P

°C

K

Pa

Pa

%

30

303.2

1,03E-01

9,11E-03

8.9%

45

318.2

1.21E+00

6.47E-02

5.4%

Conclusions:
Using the effusion method according to OECD 104 guidelines and EU method A.4, the vapour pressure for the test item is 1.71.10-2 Pa at 20°C and 4.24.10-2 Pa at 25°C.
Executive summary:

Using the effusion method (weight loss) according to OECD 104 guidelines and EU method A.4, two temperatures 30°C and 45°C were examined.

The following vapour pressure were found:

1.03.10-1 Pa at 30°C (standard deviation 9.11.10-3)

1.21 Pa at 45°C (standard deviation 6.47.10-2)

Using linear regression, the following vapour pressures for 20°C and 25°C were estimated:

1.71.10-2 Pa at 20°C

4.24.10-2 Pa at 25°C

Description of key information

the effusion method (weight loss) according to OECD 104 guidelines and EU method A.4, two temperatures 30°C and 45°C were examined.

The vapour pressure was determined using the effusion method according to OECD 104 and EU method A.4.

The vapour pressure of the test item at 20°C is

The vapour pressure of the test item at 40°C is

Using the effusion method according to OECD 104 guidelines and EU method A.4, the vapour pressure for the test item is:

- 1.71.10-2 Pa at 20°C;

- and 4.24.10-2 Pa at 25°C.

The following vapour pressure were found:
1.03 *10-1 Pa at 30°C (standard deviation 9.11 * 10-3)
1.21 Pa at 45°C (standard deviation 6.47 * 10-2)
Using linear regression, the following vapour pressures for 20°C and 25°C were estimated:
1.71 * 10-2 Pa at 20°C
4.24 * 10-2 Pa at 25°C

Key value for chemical safety assessment

Vapour pressure:
0.017 Pa
at the temperature of:
20 °C

Additional information

A key study was conducted according to OECD 104 and EU A.4 guidelines, under GLP without deviation and with certificate of analysis included. Therefore a reliability of 1 is assigned and the value obtained in this study is proposed as a key value.