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EC number: 259-370-9
CAS number: 54839-24-6
In a bacterial reverse mutation assay (Salmonella strains TA98, TA100,
TA1535, TA1537, TA1538) ethoxypropyl acetate (EPA) tested up to 5000
ug/plate did not produce evidence of mutation with or without exogenous
metabolic activation by rat liver S-9. In E. coli WP2 uvr A, the read
across substance methoxypropyl acetate did not show any signs of
In cultured Chinese hamster ovary (CHO) cells (strain K1-BH4), EPA
tested at concentrations up to 2300 ug/ml did not induce statistically
significant increases in the incidence of chromosome aberrations either
in the absence or presence of exogenous metabolic activation by rat
Propylene glycol methyl ether was not mutagenic under the conditions of
this test. This result can be considered representative of the close
structural analogue Propylene glycol ethyl ether, which is in turn the
rapidly created in vivo metabolite of Propylene glycol ethyl ether
acetate, the substance that is the subject of this dossier. On this
basis, the study indicates that Propylene glycl ethyl ether acetate
(ethoxyypropyl acetate) is not mutagenic. It should be noted that
metabolic activation was not used in this study.
In a reliable in vivo mouse micronucleus study using the surrogate
substance 1 -methoxypropan-2 -ol, which is a close structural analogue
to the key in vivo metabolite of ethoxypropyl acetate (1
-ethoxypropan-2 -ol), no increase in micronucleated polychromatic
erythrocytes was seen up to and including doses that caused mortality.
Whilst the dataset is not ideal (some surrogate substance use and one
study without metabolic activation) the evidence is sufficiently
compelling to conclude that ethoxypropyl acetate does not exhibit any
Ethoxypropyl acetate does not exhibit any mutagenic potential and
therefore does not require classification for this end point.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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