Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Model is based on accepted principles of skin permeation and diffusion of chemicals through a semi-permeable membrane. It was validated with an extensive database of experimentally measured permeation coefficients and is considered valid for substances with log Kow values in the range from 0 to 4.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR model
Title:
Skinperm version 3.0
Author:
ten Berge W
Year:
2015
Bibliographic source:
http://home.planet.nl/~wtberge/

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
human

Results and discussion

Percutaneous absorption
Remarks on result:
other:

Any other information on results incl. tables

The model estimates the permeation rate for ethoxypropyl acetate liquid to be 0.0497 mg/cm2/hr. For comparison purposes, the model estimates the permeation rate for methoxypropyl acetate to be 0.0505mg/cm3/hr and for the parent glycol ethers ethoxypropanol and methoxypropanol to be 0.223 and 0.169mg/cm2/hr respectively. This indicates that the parent ethers can absorb significantly more rapidly than the esters, by a factor of 3 -4 and that the length of the alkyl chain, at least methyl compared to ethyl has little effect on skin absorption.

Applicant's summary and conclusion

Executive summary:

A QSAR model predicts that the permeation rate of ethoxypropyl acetate will be 0.050mg/cm2/hr based on the physicochemical properties of the substance. The model predicts that the absorption is a factor of 3 -4x lower than that of the parent glycol ether.