Registration Dossier
Registration Dossier
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EC number: 201-348-8 | CAS number: 81-42-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity of CAS No.: 2872-47-1
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplusA TOXNET Database, 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of 4-Amino-4-chloroanthraquinone was performed in mouse.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 4-Amino-4-chloroanthraquinone
- Cas Number:
- 2872-47-1
- Molecular formula:
- C14H8CINO2
- IUPAC Name:
- 4-Amino-4-chloroanthraquinone
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report):4-Amino-4-chloroanthraquinone
- Molecular formula :C14H8CINO2
- Molecular weight :257.675 g/mole
- Substance type:Organic
- Physical state:No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):4-Amino-4-chloroanthraquinone
- Molecular formula :C14H8CINO2
- Molecular weight :257.675 g/mole
- Substance type:Organic
- Physical state:No data available
-Purity:No data available
- Impurities (identity and concentrations):No data available
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 1320mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 320 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 was considered to be 1320 mg/kg bw. When mouse were treated with 4-Amino-4-chloroanthraquinone (2872-47-1) orally.
- Executive summary:
In acute oral toxicity study, mice were treated with4-Amino-4-chloroanthraquinoneorally. 50% mortality was observedin treated mouse at 1320 mg/kg bw. Therefore, LD50 was considered to be 1320 mg/kg bw When mouse were treated with4-Amino-4-chloroanthraquinone(2872-47-1) orally.
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