Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
After application of a single 0.5 mL dermal dose to the shaved intact skin of rabbits for 4 hours, erythema (score of 1) was noted at the treated site of all 3 rabbits immediately following patch removal and/or at the 30-60 minute scoring interval. All animals were free of dermal irritation by 24 hours.
After instillation of 0.1 mL of test substance into the lower conjunctival sac of the eye of 3 rabbits, conjunctival redness (score of 1) and discharge (scores of 1, 2, or 3) were observed in the treated eye of all 3 rabbits at the 1-hour scoring interval. All animals were free of ocular irritation by 24 hours.
Justification for selection of skin irritation / corrosion
endpoint:
OECD guideline, GLP study
Justification for selection of eye irritation endpoint:
OECD guideline, GLP study
Justification for classification or non-classification
Although skin and eye irritation were observed, all animals were free from dermal or ocular irritation within 24 hours. Therefore, the substance does not need to be classified for skin or eye irritation according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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