Registration Dossier
Registration Dossier
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EC number: 203-233-8 | CAS number: 104-75-6
Endpoint summary
Administrative data
Description of key information
Based on results of the Mouse Ear Swelling Test, the test item is not considered to be a skin sensitizer.
In addition, the test item is classified as skin corrosive 1A. Thus, additional testing for skin sensitizing potential is waived.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
2-ethylhexylamine was evaluated for dermal sensitization in 10 mice by Mouse Ear Swelling Test (Sensitization Assay). Induction consisted of 5% topical application of the test and/or control material to the clipped abdomen. The test and positive control animals were challenged on day 10 on the left ear and re-challenged on day 17 on the right ear with a 25% solution of test substance. Few animals challenged showed weakly positive reactions at challenge or re-challenge in the test group, but not in the irritation control group. The test provided no evidence of a sensitising potential of 2-ethylhexylamine. The functionality of the test system was demonstrated by using an appropriate positive control substance which was clearly positive.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. The substance is not considered to be classified as skin sensitizer under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EC) No 2017/776.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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