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EC number: 203-233-8 | CAS number: 104-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
No valid neurotoxicity studies for 2-ethylhexylamine are available. However, a read-across to a reproduction/developmental toxicity screening test according to OECD guideline 422 with octylamine hydrochloride is available (ACC, Oxea Group 2007) in which neurobehavioural observations were included. There were no treatment related effects or statistically significant differences on forelimb and/or hindlimb grip strength. In the open field observation no changes were seen in any dosage of the test substance analogue. Regarding motor activity, there was a trend of reduced number and duration of movements in males and females compared with controls at 150/100 mg/kg bw/day which seems to be related to a general bad condition of the animals. The neurobehavioral NOAEL was therefore 100 mg/kg bw/day for male and female rats in the OECD TG 422 study.
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 100 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Reproduction/developmental screening test according to Guideline study and performed under GLP conditions in which neurobehavioural observations were included.
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Potential effects of octylamine on neurobehavior were examined in the combined repeated dose and reproduction/developmental toxicity study according to OECD 422. Male and female rats were given 0, 37.5, 75, and 150 mg octylamine hydrochloride/kg bw/day by oral gavage, starting 14 days prior mating. The dose level was decreased to 100 mg/kg bw/day after premating period (day 14) due to mortalities (3 animals); autopsy suggested an intubation accident aggravated by the irritation from the test substance.
There were no treatment related effects or statistically significant differences on forelimb or hindlimb grip strength. In the open field observation no changes were seen at any dosage of the test substance. Regarding motor activity, there was a trend of reduced number and duration of movements in males and females compared with controls at 150/100 mg/kg bw/day. No treatment related changes in grip strength, response to tail pinch, approach and touch and auditory stimulus parameters were seen. Since mortality, effects on body weight, food consumption, and clinical observations occurred at 150/100 mg/kg bw/day, the lower motor activity seems to be related to a general bad condition of animals than to neurotoxic effects of the test substance. The neurobehavioral NOAEL was therefore 100 mg/kg bw/day for male and female rats in the OECD 422 study (ACC, Oxea group 2007).
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result the substance is not considered to be classified with respect to neurotoxicity after repeated dosing via oral route under Regulation (EC) No 1272/2008, as amended for the ninth time in Regulation (EU) No 2016/1179.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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