Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 260-486-7 | CAS number: 56973-85-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 March to 18 April 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an internationally recognized method, and under GLP. No deviation was reported. Test substance is adequately specified with purity. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP compliance programme (inspected on 05 July 2016 / signed on 28 October 2016)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.1
- Temp.:
- 25 °C
- pH:
- 7.2
- Conclusions:
- The substance has potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log10Pow >4).
- Executive summary:
The partition coefficient of the test substance was measured under GLP according to the OECD 117/EU A8 guideline, HPLC method.
The system was calibrated with 6 reference substances, and the results for the duplicate determinations of the sample were interpolated from the linear regression. The mean value, rounded for accuracy, was retained.
The partition coefficient (Pow) of the test item has been determined to be 1.4 x 104, log10Pow 4.1.
Reference
Preliminary Estimate
The log10Pow was calculated to be: 4.4
Main Test
Table 4.7/1: Partition coefficient of sample
Injection
|
Retention time (mins)
|
Capacity factor (k′)
|
Log10k'
|
Log10Pow
|
1 |
4.606 |
2.40 |
0.381 |
4.14 |
2 |
4.592 |
2.39 |
0.379 |
4.13 |
Mean log10Pow: 4.1
Partition coefficient: 1.4 x 104
Description of key information
The substance has potential for bioaccumulation, according to CLP classification criteria for aquatic chronic toxicity (log Kow >4).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.1
- at the temperature of:
- 25 °C
Additional information
A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. The result is retained as key data for purpose of CSA.
An additional study is provided on the degradation product, for PBT and ecotoxicoloical assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
