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EC number: 209-608-2 | CAS number: 587-98-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- A case of allergic contact dermatitis due to metanil yellow
- Author:
- Hausen BM
- Year:
- 1 994
- Bibliographic source:
- Contact Dermatitis 31: 117–118, 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To evaluate the skin sensitizing potential of substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate in human by patch test.
- GLP compliance:
- not specified
- Type of study:
- patch test
- Justification for non-LLNA method:
- Case report of contact dermatitis proceeded by patch test.
Test material
- Reference substance name:
- Sodium 3-(p-anilinophenylazo)benzenesulphonate
- EC Number:
- 209-608-2
- EC Name:
- Sodium 3-(p-anilinophenylazo)benzenesulphonate
- Cas Number:
- 587-98-4
- Molecular formula:
- C18H14N3O3S.Na
- IUPAC Name:
- sodium 3-(p-anilinophenylazo)benzenesulphonate
- Test material form:
- solid
- Details on test material:
- - Name of test material: Ext. D&C Yellow No. 1
- IUPAC name: sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate
- Molecular formula: C18H15N3O3SNa
- Molecular weight: 375.383 g/mol
- Substance type: organic
- Physical state: solid
- Purity: No data available
- Impurities (identity and concentrations): no data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material : sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate
- Molecular formula : C18H14N3O3S.Na
- Molecular weight: 375.383 g/mol
- Smiles notation : c1(Nc2ccccc2)ccc(\N=N\c2cc(ccc2)S(=O)(=O)[O-])cc1.[Na+]
- InChl : 1S/C18H15N3O3S.Na/c22-25(23,24)18-8-4-7-17(13-18)21-20-16-11-9-15(10-12-16)19-14-5-2-1-3-6-14;/h1-13,19H,(H,22,23,24);/q;+1/p-1/b21-20+;
- Substance type: Organic
- Physical state: Solid
In vivo test system
Test animals
- Species:
- other: human
- Strain:
- other: not applicable
- Sex:
- female
- Details on test animals and environmental conditions:
- No data
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: dermal
- Vehicle:
- not specified
- Concentration / amount:
- not specified
- Day(s)/duration:
- 4 days
- Adequacy of induction:
- not specified
- No. of animals per dose:
- 1 human female
- Details on study design:
- Not specified
- Challenge controls:
- Not specified
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 96
- Group:
- test chemical
- Dose level:
- not specified
- No. with + reactions:
- 3
- Clinical observations:
- lesions were observed
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- The substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate was observed to show positive reactions in Human patch test for skin sensitisation.
- Executive summary:
A female patient worked in a leather (and paper) shop, selling various leather items, such as purses, pocket books, photo albums, document portfolios, wallets and writing cases. Whenever she worked in this shop, which was usually for 2 days a week, she developed dermatitis on left side of the neck. Hence the patch test was carried out for the test substance. Patch test with the scrapings of the material remained negative. However, patch testing with the leather series gave a +++ reaction to the test substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate (acid yellow/metanil yellow) at 2, 3 and 4 days. On giving up working in this shop, and subsequent avoidance of contact with leather articles, her lesions healed completely. Therefore, the test substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate was considered to be a skin sensitiser and can be classified as Skin sensitiser category 1 according to CLP criteria.
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