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Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
Internationally accepted method, ECOSAR, EPA (USA)
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF)
GLP compliance:
no
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
17 500 000 mg/L
Remarks on result:
other: Estimated 96-h LC50 for Fish (ECOSAR v1.00a, Triazines)
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
269 000 mg/L
Remarks on result:
other: Estimated 96-h LC50 for Fish (ECOSAR v1.00a, Aliphatic amines)
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1 270 000 mg/L
Remarks on result:
other: Estimated 96-h LC50 for Fish (ECOSAR v1.00a, Baseline toxicity)
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 96-h LC50 for fish was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.
Executive summary:

The estimated 96-h LC50 for fish was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
Internationally accepted method, ECOSAR, EPA (USA)
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF)
GLP compliance:
no
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
5 080 000 mg/L
Remarks on result:
other: Estimated 96-h LC50 for Fish (ECOSAR v1.00a, Triazines)
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
269 000 mg/L
Remarks on result:
other: Estimated 96-h LC50 for Fish (ECOSAR v1.00a, Aliphatic amines)
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
532 000 mg/L
Remarks on result:
other: Estimated 96-h LC50 for Fish (ECOSAR v1.00a, Baseline toxicity)
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 96-h LC50 for fish was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.
Executive summary:

The estimated 96-h LC50 for fish was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
Internationally accepted method, ECOSAR, EPA (USA)
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF)
GLP compliance:
no
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1 470 000 mg/L
Remarks on result:
other: Estimated 96-h LC50 for Fish (ECOSAR v1.00a, Triazines)
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
269 000 mg/L
Remarks on result:
other: Estimated 96-h LC50 for Fish (ECOSAR v1.00a, Aliphatic amines)
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
222 000 mg/L
Remarks on result:
other: Estimated 96-h LC50 for Fish (ECOSAR v1.00a, Baseline toxicity)
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 96-h LC50 for fish was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.
Executive summary:

The estimated 96-h LC50 for fish was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.

Description of key information

Weight of evidence: ECOSAR v1.00a for Triazines, Aliphatic amines and Baseline toxicity. The estimated 96-h LC50 for fish for the three constituents of the test item, were found to be much higher than 100 mg/L.

Supporting study: Read-across from experimental data on P0310. Test method OECD 203. GLP study. The 96-hour NOEC and the 96-hour LC0 to zebra fish were determined to be 100 mg/L.

Key value for chemical safety assessment

LC50 for freshwater fish:
100 mg/L

Additional information

Weight of evidence: The estimated 96-h LC50 for fish for the three constituents of the test item, were found to be much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines, Aliphatic amines and Baseline toxicity.

Supporting study: Based on the read-across approach from experimental data on the analogue P0310 (OECD Guideline 203, GLP study), the 96-hour NOEC and the 96-hour LC0 to zebra fish were determined to be 100 mg/L (mean measured concentration of 93 mg/L).