Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96h) > 240 µg/L (nominal) (Danio rerio, OECD 203); no adverse effects up to the limit of the water solubility
Key value for chemical safety assessment
Additional information
A study on the short-term toxicity of the test substance towards fish was conducted by Clarke (2013). The study was conducted according to GLP and followed OECD guideline 203. Danio rerio were exposed for 96 hours in a static test system. Test concentrations were prepared by aid of methanol as solvent and ranged from 15 to 240 µg/L, i.e. the highest test concentration being the limit of the water solubility. Analytical measurements of the test concentrations were performed. Concentrations were found to be in the range of the nominal values. No adverse effects were observed during the test. Thus, a study on the short-term toxicity of the test substance towards Daphnia magna was conducted by Micevska (2013). The study was conducted according to GLP and followed OECD guideline 202. Daphnids were exposed for 48 hours in a static test system. Test concentrations were prepared without a solvent and ranged from 6.4 to 100.2 mg/L, thus above the limit of water solubility. Test concentrations were filtered through a 3 µm glass fiber filter. Analytical measurements of the test concentrations were performed. Concentrations were found to be in the range of the water solubility. No adverse effects were observed during the test. Thus, there are no effects up to the limit of the water solubility and the EC50 (96h) was determined to be >240 µg/L based on nominal concentrations.
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