2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-, (2E)-

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 01/10/1986 to 15/10/1986

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

as adopted on 12th May 1981

Deviations:

no

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

(E)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol

Cas Number:

106155-02-6

Molecular formula:

C13H22O

IUPAC Name:

(E)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol

impurity 1

Reference substance name:

(Z)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol

Cas Number:

106155-03-7

Molecular formula:

C13H22O

IUPAC Name:

(Z)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol

impurity 2

Reference substance name:

Unknown impurities

IUPAC Name:

Unknown impurities

Test material form:

other: clear liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

one group of animals, comprising 5 males and 5 females, was treated with a single dermal dose of the test substance at 2000 mg/kg of bodyweight

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

see attachement

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The test item should not be classified for acute dermal toxicity in accordance with GHS system and CLP regulation Regulation (EC) No 1272/2008

Executive summary:

One group of Wistar rats, comprising 5 males and 5 females, was treated with a single dermal dose of the test item at 2000 mg/kg bodyweight for 24 hours. No mortalities occurred and no signs of systemic toxicity were observed during exposure and the following 14 -day observation period.

The treated skin surface of the animals showed areas with erythema and scales. These lesions disappeared during the second week of observation. Macroscopic examination of all animals at the end of the study revealed no test substance related gross abnormalities. Since no mortalities occurred, the LD50 value for males and females combined was estimated to exceed 2.0 g/body weight.