Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-774-1 | CAS number: 72-19-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
It can be concluded that L-threonine is rapidly oxidized in activated sludge. This leads to the conclusion that it does not show toxic effects to the microorgnism population of activated sludges.
Key value for chemical safety assessment
Additional information
DL-Threonine did not show significant toxic effects to the population of microrganisms in waste water (activated sludge) at a nominal concentration of 500 mg/l. Read-across from DL-threonine to L-threonine was applied because of similar physico-chemical characteristics, a similar toxicological/ecotoxicological profile and the structural similarity of racemic threonine to the enantiomer L-threonine. One can expect that the equivalent concentrations of L-threonine will not show toxic effects in this test system. Instead of DL-threonine, L-threonine is a natural constituent of most living cells, is involved in many metabolic pathways and more subject to undergo biodegradation.
Further, in another not well documented study 18 amino acids were examined for biodagradability and toxic degradation inhibition. In this study L-threonine in aconcentration of approx. 210 mg/l shows no toxic inhibition (0%) according to Offhaus.
The summation of results leads to the conclusion that L-threonine is readily biodegradable and non-toxic to sludge microorganisms.
In accordance with REACH Annex VIII, No. 9.1.4 column 2, the toxicity test to microorganisms does not need to be conducted as there are mitigating factors indicating that the microbial toxicity is unlikely to occur as well as because the substance is readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
