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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
no hazard identified

Marine water

Hazard assessment conclusion:
no hazard identified

STP

Hazard assessment conclusion:
no hazard identified

Sediment (freshwater)

Hazard assessment conclusion:
no hazard identified

Sediment (marine water)

Hazard assessment conclusion:
no hazard identified

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
no hazard identified

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

For the assessment of the short-term toxicity of Creatinine to aquatic freshwater organisms two reliable study according to standard guidelines are available. In both studies Creatinine do not induce any negative effects on aquatic freshwater organism.

The acute toxicity of Creatinine on Daphnia magna was determined in a 48 hours static test following the pattern of EEC Commission Directive 92/69, C.2 "Acute Toxicity for Daphnia magna". Animals of Daphnia magna, not more than 24 hours old, were exposed to different concentrations of the test substance in reconstituted water according to ISO 6341. A negative control group was exposed to reconstituted water only. In the test 20 daphnids, divided into 4 replicates (5 daphnia each) were used for each concentration and for the control group. The results show that at a test substance concentration of 1000 mg/L no daphnids were immobilized. Therefore the EC50 of Creatinine is > 1000 mg/L.

A second study was performed in order to evaluate the toxic potential of Creatinine towards Pseudokirchneriella subcapitata according to OECD Guideline No. 201 ("Freshwater Alga and Cyanobacteria, Growth Inhibition Test").Initial concentration of 0.5 × 104 cells/mL in each test vessel, were exposed in a static test system for 72 hours.A static limit test (range-finding test in limit test design) with concentrations of 1.00, 10.0, 100 mg/L and control was performed.Six replicates were tested for the controland the highest test item concentrationand three for the other test item concentrations.After 24, 48 and 72 hours, the cell growth was determined by fluorescence detection. The mean value of the cell concentration was plotted versus time to produce growth curves for each concentration. EC values (ErC50, EyC50, NOEC, LOEC) were calculated.Analytical samples were taken from the highest test item concentration and from the control after 0, 24, 48 and 72 hours. All samples were analysed at 0 and 72 hours to verify the actual test concentration using a validated analytical method.

No inhibitory effects were observed for the test substance Creatinine up to the highest concentration of 100 mg/L (nominal). The EC50-value for growth rate (ErC50) and yield (EyC50) was > 100 mg/L (nominal). The LOEC was determined to be > 100 mg/L (nominal) and the NOEC was determined to be 100 mg/L (nominal) for the parameters growth rate and yield.

Conclusion on classification

According to the above mentioned results Creatinine does not have to be classified.